Covers the use of GC-MS in chemical analysis. The course starts with a general discussion of the theory of mass spectrometry as applied to the field of GC-MS. Types of GC-MS are then compared. Subsequent sections of the course cover topics that relate to more advanced aspects of GC-MS including instrument components, modes of operation and the interpretation of GC-MS spectra. Other topics discussed include the optimization of quantitative and qualitative analyses using GC-MS and routine troubleshooting and maintenance of selected GC-MS instruments. Laboratory exercises provide practical training of the principles covered in the lectures.
- Extensive GC knowledge or CHEM 5001.
- Not offered this term
- This course is not offered this term. Please check back next term or subscribe to receive notifications of future course offerings and other opportunities to learn more about this course and related programs.
Upon successful completion, the student will be able to:
- Demonstrate a thorough knowledge of the general theory of mass spectrometry where relevant to the field of gas chromatography - mass spectrometry (GC/MS).
- Discriminate the types of GC/MS according to their features and usage.
- Compare the various component options commonly found in GC/MS instruments
- Diffusion pumps - turbomolecular vs. diffusion.
- Modes of ionization - electron impact (EI) vs. chemical ionization (CI).
- Ion monitoring techniques - Positive vs. negative ion methods.
- Interpret EI and CI GC/MS data.
- Explain the general steps involved in the operation of GC/MS systems.
- Compare GC/MS tuning procedures and analyse results from common tuning methods to plan GC/MS maintenance.
- Discriminate SIM and SCAN modes of operation in GC/MS.
- Optimise methods for qualitative and quantitative analysis using GC/MS.
- Develop strategies for quantitative and qualitative analysis in GC/MS using common software packages.
- Design procedures for method transfer between GC/FID and GC/MS systems.
- Plan and implement preventative maintenance procedures for use with GC/MS.
- Select the correct logical steps involved in GC/MS troubleshooting.
- Assess the versatility of derivatisation methods in GC/MS.
- Select appropriate internal standards for GC/MS analysis.
- Rank library search strategies commonly used in GC/MS.
Effective as of Fall 2007
Interested in being notified about future offerings of GC/MS and Applications (CHEM 5006)? If so, fill out the information below and we'll notify you by email when courses for each new term are displayed here.
Programs and courses are subject to change without notice.