Course Overview
This course covers topics of general chemistry relevant for the study of Nuclear Medicine - concentrations and properties of solutions, oxidation and reduction, intermolecular forces and buffers. Coordination chemistry and inorganic compounds are introduced with reference to chelating agents used as radiopharmaceuticals. Chromatography and separation techniques are introduced with emphasis on applications to Nuclear Medicine Technology. The term ends with an introduction to organic chemistry. The functional groups of the major families in organic chemistry are introduced, and the physical and chemical properties of the hydrocarbons are described. Chirality and the significance of stereochemistry are discussed. As these topics are studied, applications to Nuclear Medicine Technology are emphasized.
Prerequisite(s)
- No prerequisites are required for this course.
Credits
3.0
- Not offered this term
- This course is not offered this term. Notify me to receive email notifications when the course opens for registration next term.
Learning Outcomes
Upon successful completion of this course, the student will be able to:
- Assign oxidation numbers and balance redox equations with emphasis on those used in Nuclear Medicine.
- Calculate concentrations of solutions in the units used in the clinical lab e.g. molarity, percent, molality.
- Describe the properties of the colloids used in Nuclear Medicine.
- Determine the osmolarity of a solution and relate it to plasma osmolarity.
- List examples of simple coordination compounds.
- Identify the functional groups of the major organic families.
- List structural formulas, names, and the main physical and chemical properties of the alkanes, alkenes and aromatic hydrocarbons.
- Identify the structural features that give rise to formation of the different types of stereoisomers and give examples that illustrate the importance of stereochemistry in biological systems and in the design of pharmaceuticals.
- Distinguish between polar (hydrophilic) and non-polar (lipophilic) organic compounds, predict the physical state and solubility characteristics of these compounds and explain how these affect the biodistribution of pharmaceuticals.
- Describe properties and characteristics of ligands and chelating agents. Describe the process of transchelation and how it relates to the preparation of radiopharmaceuticals.
- Identify molecules and ions that can act as ligands and chelating agents and learn about the chemical characteristics of chelates used as radiopharmaceuticals, (DTPA, MIBI, Oxine, HMPAO, IDA, DMSA, tetrofosmin, pyrophosphate, MDP).
- Evaluate different chromatographic methods and, for each of these methods, understand the parameters which influence the resolution and efficiency of separation of components in a mixture and predict how to modify parameters to improve separation.
- Describe how the structure, or composition, of a buffer functions to resist changes in pH.
- Explain how a change in pH can affect the charge of a molecule. Predict the charge of a peptide or protein based on its isoelectric pH.
Effective as of Fall 2016
Programs and courses are subject to change without notice. Find out more about BCIT course cancellations.